P/D– Stops protein synthesis of bacteria and hence stops bacterial multiplication.
Chloramphenicol is a broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections.
Route of administration-
•Oral route
•Intravenous route
•Injection route
Contraindications-
•Not used in neonates
•Avoid during breast feeding
•Hypersensitivity
Adverse effects-
•Bone marrow toxicity- Risk of aplastic Anemia , leukaemia
•Collapse of cardiovascular system- This occurs specially in neonates and may lead to grey baby syndrome
Basically chloramphenicol is a good drug but is not used frequently because of its high risk bone marrow toxicity.
Uses-
•Chloramphenicol is more effective against gram negative bacteria
•They are less effective against gram positive bacteria
•They can’t act against atypical bacteria,so it is useless to use chloramphenicol in a person affected with atypical bacterial infection.
We mainly use chloramphenicol against gram negative bacteria like-
Bordetela pertusis- it causes whooping cough (pertusis)
Haemophilus influenzae- causing meningitis
Salmonella typhi- causes typhoid
Contributor- Medico Anant Singh Nanda
